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KMID : 1134819970260020319
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 2 p.319 ~ p.326
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Effect of Methionine and Selenium Levels on Alcohol Metabolic Enzyme System in Rats
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Kim Myung-Joo
Park Eun-Mi
Lee Mi-Kyung
Cho Soo-Yeul
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Abstract
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This study was conducted to investigate the effects of methionine(Met) arid selenium(Se) levels on alcohol metabolic enzyme system in rats. Sprague-Dawley male rats were fed on diets containing one of the three levels of Met(0, 3, 9g/㎏ diet) with or without Se(0.45㎎/㎏ diet). Alcohol was administrated with 25%(v/v) ethanol orally at the same time once a day in alcohol group and isocaloric sucrose was administrated to the control group. The rats were sacrificed after 5 and 10 week of feeding periods. Alcohol dehydrogenase(ADH) and microsomal ethanol oxidizing system(MEOS) activities of hepatic tissue-dom were increased more in alcohol treated groups than control group. Increment of activities preinated in simultaneous deficiency of dietary Met and Se(LMet-Se+EtOH) group. Aldehyde dehydrogenase (AlDH) activity was decreased more in alcohol treated groups than control group and significantly decreased in Met and Se supplemented(NMet+Se+EtOH) group. Hepatic cytochrome P-450 content and xanthine oxidase(XO) activity were significantly increased in alcohol treated groups Compared to control group and predominated in Met deficiency(LMet) group and excessive Met administration (HMet) group. Superoxide dismutase(SOD), catalase, glutathione S-transferase(GST) activities tended to increase by alcohol administration, the degree of increase predominated in 10 week. The activity of glutathione peroxidase(GSH-Px) was decreased in alcohol groups and tended to increase in proportion to the level of dietary Met.
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KEYWORD
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methionine, selenium, alcohol metabolic enzyme system
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